steroidal glycoside

By Targets:	Amyloid-β (1) Biochemical Assay Reagents (1) Calcium Channel (1) Glucosidase (1) NF-κB (1) PPAR (1) Sirtuin (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (2)

Targets Recommended: Steroid Sulfatase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8659

Uzarin

Uzarigenin 3-β-sophoroside
Others Others

Uzarin is a steroid glycoside. Uzarin does not inhibit cell proliferation or induce apoptosis .
HY-N12380

Stauntoside M

Others Others

Stauntoside M is a steroidal glycoside that can be isolated from the Roots of Cynanchum stauntonii .
HY-N12066

Progenin III palmitate

Others Others

Progenin III palmitate is a steroid glycoside ester isolated from Dioscorea cayenensis rhizomes .
HY-N9385

Proprotogracillin

Others Others

Proprotogracillin is a steroidal glycoside isolated from the bulbs of lilium speciosum .
HY-107307

Ophiopojaponin A

Others Others

Ophiopojaponin A is a steroidal glycoside that can be isolated from Polygonatum glaberrimum .

Uzarin Uzarigenin 3-β-sophoroside	Others	Others
Uzarin is a steroid glycoside. Uzarin does not inhibit cell proliferation or induce apoptosis .

Stauntoside M	Others	Others
Stauntoside M is a steroidal glycoside that can be isolated from the Roots of Cynanchum stauntonii .

Progenin III palmitate	Others	Others
Progenin III palmitate is a steroid glycoside ester isolated from Dioscorea cayenensis rhizomes .

Proprotogracillin	Others	Others
Proprotogracillin is a steroidal glycoside isolated from the bulbs of lilium speciosum .

Ophiopojaponin A	Others	Others
Ophiopojaponin A is a steroidal glycoside that can be isolated from Polygonatum glaberrimum .

HY-N1375

Qingyangshengenin	Others	Cancer
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity .

HY-129217

Naringinase	Glucosidase	Others
Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase has wide occurrence in nature. Naringinase can be used in the biotransformation of steroids, antibiotics, and mainly on glycosides hydrolysis .

HY-N2175

Cixiophiopogon A

Cixiophiopogon A, a steroidal glycoside, obtained from the tuberous roots of Ophiopogon japonicus (Liliaceae) .
HY-N12724

Stauntoside R

Others Others

Stauntoside R (compound 4) is a steroidal glycoside that can be isolated from the roots of Xu Changqing .
HY-N1432

Lirioprolioside B

Lirioprolioside B is a steroidal glycoside that can be isolated from the underground organs of Liriope spicata var. prolifera .
HY-N1962

Ophiopojaponin C

Ophiopojaponin C is a naturally occurring C₂₉ steroidal glycoside isolated from the tubers of O. japonicas .
HY-N0581

Qingyangshengenin A

Others Neurological Disease

Qingyangshengenin A, a C-21 steroidal glycoside isolated from the roots of Cynanchum otophyllum Schneid, has antiepileptic activity .

Cixiophiopogon A
Cixiophiopogon A, a steroidal glycoside, obtained from the tuberous roots of Ophiopogon japonicus (Liliaceae) .

Stauntoside R	Others	Others
Stauntoside R (compound 4) is a steroidal glycoside that can be isolated from the roots of Xu Changqing .

Lirioprolioside B
Lirioprolioside B is a steroidal glycoside that can be isolated from the underground organs of Liriope spicata var. prolifera .

Ophiopojaponin C
Ophiopojaponin C is a naturally occurring C₂₉ steroidal glycoside isolated from the tubers of O. japonicas .

Qingyangshengenin A	Others	Neurological Disease
Qingyangshengenin A, a C-21 steroidal glycoside isolated from the roots of Cynanchum otophyllum Schneid, has antiepileptic activity .

HY-N1217

Stauntosaponin A Stauntoside C
Stauntosaponin A, a steroid glycoside, is a potent inhibitor of Na(+)/K(+)-ATPase with an IC₅₀ value of 21 nM. Stauntosaponin A can be isolated from Carnation and has potential anti-cancer research value .

HY-N11912

Soladulcoside A	Biochemical Assay Reagents	Cancer
Soladulcoside A is a steroidal glycoside and antineoplastic agent that can be obtained from the whole plant of Solanum nigrum. Soladulcoside A can inhibit A549 cells and has the potential to study cancers such as non-small cell lung cancer (NSCLC) .

HY-N0582

Otophylloside B	Amyloid-β	Neurological Disease
Otophylloside B, a C-21 steroidal glycoside isolated from Qingyangshen. Otophylloside B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Otophylloside B has antiepileptic activity .

HY-N12720

Cynanoside J	Others	Cancer
Cynanoside J is a C₂₁ steroidal glycosides that can be obtained from Cynanchum taihangense. The IC₅₀ values of Cynanoside J for HL-60, THP1, and Caco2 are 6.38, 5.82, and 6.76 μM, respectively. Cynanoside J can be used in cancer research .

HY-N6061

Ophiopogonin C	Others	Cancer
Ophiopogonin C, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin C shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC₅₀s of 19.76 μM and 15.51 μM, respectively .

HY-B2151

Digitoxigenin Cerberigenin; Echujetin
Digitoxigenin is a steroid derivative commonly found in various plants, especially the foxglove plant (Digitalis purpurea). Digitoxigenin has unique chemical properties that make it an important precursor for the synthesis of cardiac glycosides, a group of drugs used to improve heart failure and certain types of arrhythmias. It works by inhibiting the sodium potassium ATPase pump, thereby increasing the force and efficiency of cardiac contractions.

HY-N3504

Ophiopogonin D'	Sirtuin	Cancer
Ophiopogonin D', isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D' shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC₅₀s of 3.09 μM and 3.63 μM, respectively . Ophiopogonin D' activates SIRT1 in a dose-dependent manner .

HY-N12002

Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside	Others	Others
Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside (compound 9) is a steroidal saponin, which can be obtained from Paris polyphylla var., Yunnan pine (yunnanensis) Isolated .

HY-N0515

Ophiopogonin D	PPAR NF-κB Calcium Channel	Cardiovascular Disease Inflammation/Immunology
Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years .

Cat. No.	Product Name

HY-L021

Natural Product Library	4560 compounds
Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery. Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. With the development of new molecular targets, there is an increasing demand for novel molecular diversity for screening. Natural products will play a crucial role in meeting this demand through the continued investigation of world’s bio-diversity, much of which remains unexplored. MCE provides a unique collection of 4560 natural compounds that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Natural Product Library

4560 compounds

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery.

Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. With the development of new molecular targets, there is an increasing demand for novel molecular diversity for screening. Natural products will play a crucial role in meeting this demand through the continued investigation of world’s bio-diversity, much of which remains unexplored.

MCE provides a unique collection of 4560 natural compounds that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

HY-L021P

Natural Product Library Plus	5334 compounds
Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery. Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. With the development of new molecular targets, there is an increasing demand for novel molecular diversity for screening. Natural products will play a crucial role in meeting this demand through the continued investigation of world’s bio-diversity, much of which remains unexplored. MCE provides a unique collection of 5334 natural compounds that contains Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library Plus, with more powerful screening capability, further complements Natural Product Library (HY-L021) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

Natural Product Library Plus

5334 compounds

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery.

Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. With the development of new molecular targets, there is an increasing demand for novel molecular diversity for screening. Natural products will play a crucial role in meeting this demand through the continued investigation of world’s bio-diversity, much of which remains unexplored.

MCE provides a unique collection of 5334 natural compounds that contains Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library Plus, with more powerful screening capability, further complements Natural Product Library (HY-L021) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

HY-L163

FDA-Approved Traditional Chinese Medicine Active Compound Library	333 compounds
Traditional Chinese medicine provides abundant natural resources for medicinal compounds, which are often considered effective and safe for drug discovery. Traditional Chinese medicine is based on the principle of "multiple components, multiple targets, and multiple pathways", and naturally has multiple pharmacological effects. As herbal medicine, the secondary plant metabolites in Chinese herbal medicine play an important role in alleviating many diseases in Traditional medicine and folk use. Therefore, the identification of traditional Chinese medicine derived compounds is also an important process in drug development and a necessary factor in dissecting the overall mechanism of action of traditional Chinese medicine. FDA listed compounds have completed extensive preclinical and clinical studies, exhibiting good biological activity, safety, and bioavailability. MCE designs a unique collection of 333 FDA-approved traditional Chinese medicine active compounds, including flavonoids, polyphenols, alkaloids, terpenoids, and other structural types. It is a good tool for drug reuse and screening drugs from traditional Chinese medicine sources.

FDA-Approved Traditional Chinese Medicine Active Compound Library

333 compounds

Traditional Chinese medicine provides abundant natural resources for medicinal compounds, which are often considered effective and safe for drug discovery. Traditional Chinese medicine is based on the principle of "multiple components, multiple targets, and multiple pathways", and naturally has multiple pharmacological effects. As herbal medicine, the secondary plant metabolites in Chinese herbal medicine play an important role in alleviating many diseases in Traditional medicine and folk use. Therefore, the identification of traditional Chinese medicine derived compounds is also an important process in drug development and a necessary factor in dissecting the overall mechanism of action of traditional Chinese medicine. FDA listed compounds have completed extensive preclinical and clinical studies, exhibiting good biological activity, safety, and bioavailability.

MCE designs a unique collection of 333 FDA-approved traditional Chinese medicine active compounds, including flavonoids, polyphenols, alkaloids, terpenoids, and other structural types. It is a good tool for drug reuse and screening drugs from traditional Chinese medicine sources.

HY-L065

Traditional Chinese Medicine Active Compound Library	2861 compounds
Chinese herbal therapy is an important part of Traditional Chinese Medicine (TCM). It has been used for centuries in China, where herbs are considered fundamental therapy for many acute and chronic conditions. Many studies indicated TCM exerted an overall regulatory effect via multi-component and multi-target network. Active components from Traditional Chinese Medicine possess many medicinal properties such as antioxidant, anti-cancer, and anti-bacterial effects, which makes it an important source of new drugs. Nearly 200 modern medicines have been developed either directly or indirectly from the plants used as medicines in China. For example, artemisinin, used in multidrug resistant malaria, was first isolated from the Chinese herb Artemisia annua L. Today, scientists continue to identify compounds in Chinese herbal remedies that may be useful in the development of new therapeutic agents applicable in Western medicine. MCE designs a unique collection of 2861 active compounds of Chinese Herbal Medicines. MCE Traditional Chinese Medicine Active Compound Library is a useful tool for discovery new drugs from TCM.

Traditional Chinese Medicine Active Compound Library

2861 compounds

Chinese herbal therapy is an important part of Traditional Chinese Medicine (TCM). It has been used for centuries in China, where herbs are considered fundamental therapy for many acute and chronic conditions. Many studies indicated TCM exerted an overall regulatory effect via multi-component and multi-target network. Active components from Traditional Chinese Medicine possess many medicinal properties such as antioxidant, anti-cancer, and anti-bacterial effects, which makes it an important source of new drugs. Nearly 200 modern medicines have been developed either directly or indirectly from the plants used as medicines in China. For example, artemisinin, used in multidrug resistant malaria, was first isolated from the Chinese herb Artemisia annua L. Today, scientists continue to identify compounds in Chinese herbal remedies that may be useful in the development of new therapeutic agents applicable in Western medicine.

MCE designs a unique collection of 2861 active compounds of Chinese Herbal Medicines. MCE Traditional Chinese Medicine Active Compound Library is a useful tool for discovery new drugs from TCM.

Cat. No.	Product Name	Type

HY-129217

Naringinase	Biochemical Assay Reagents
Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase has wide occurrence in nature. Naringinase can be used in the biotransformation of steroids, antibiotics, and mainly on glycosides hydrolysis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8659

Uzarin Uzarigenin 3-β-sophoroside	Structural Classification Polysaccharides Source classification Cucurbitaceae Plants Bolbostemma paniculatum (Maxim.) Franquet Saccharides Steroids	Others
Uzarin is a steroid glycoside. Uzarin does not inhibit cell proliferation or induce apoptosis .

HY-N12380

Stauntoside M	Apocynaceae Structural Classification Natural Products Source classification Plants Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li	Others
Stauntoside M is a steroidal glycoside that can be isolated from the Roots of Cynanchum stauntonii .

HY-N12066

Progenin III palmitate	Structural Classification Cardiacglycosides Source classification Plants Dioscorea cayenensis Lam. Steroids Dioscoreaceae	Others
Progenin III palmitate is a steroid glycoside ester isolated from Dioscorea cayenensis rhizomes .

HY-N9385

Proprotogracillin	Liliaceae Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields Lilium brownie var. viridulum Steroids	Others
Proprotogracillin is a steroidal glycoside isolated from the bulbs of lilium speciosum .

HY-107307

Ophiopojaponin A	Polygonatum glaberrimum K.Koch Structural Classification Source classification Plants Steroids Asparagaceae Juss.	Others
Ophiopojaponin A is a steroidal glycoside that can be isolated from Polygonatum glaberrimum .

HY-N1375

Qingyangshengenin	Monophenols Classification of Application Fields Source classification Asclepiadaceae Phenols Cynanchum otophyllum Schneid． Plants Disease Research Fields Steroids Cancer	Others
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity .

HY-129217

Naringinase	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Glucosidase
Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase has wide occurrence in nature. Naringinase can be used in the biotransformation of steroids, antibiotics, and mainly on glycosides hydrolysis .

HY-N12724

Stauntoside R	Apocynaceae Structural Classification Cardiacglycosides Source classification Plants Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li Steroids	Others
Stauntoside R (compound 4) is a steroidal glycoside that can be isolated from the roots of Xu Changqing .

HY-N0581

Qingyangshengenin A	Structural Classification Monophenols Source classification Asclepiadaceae Phenols Cynanchum otophyllum Schneid． Plants Steroids	Others
Qingyangshengenin A, a C-21 steroidal glycoside isolated from the roots of Cynanchum otophyllum Schneid, has antiepileptic activity .

HY-N11912

Soladulcoside A	Structural Classification Source classification Solanum nigrum Linn. Plants Solanaceae Steroids	Biochemical Assay Reagents
Soladulcoside A is a steroidal glycoside and antineoplastic agent that can be obtained from the whole plant of Solanum nigrum. Soladulcoside A can inhibit A549 cells and has the potential to study cancers such as non-small cell lung cancer (NSCLC) .

HY-N0582

Otophylloside B	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Asclepiadaceae Cynanchum otophyllum Schneid． Plants Disease Research Fields Steroids	Amyloid-β
Otophylloside B, a C-21 steroidal glycoside isolated from Qingyangshen. Otophylloside B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Otophylloside B has antiepileptic activity .

HY-N12720

Cynanoside J	Apocynaceae Structural Classification Cardiacglycosides Source classification Plants Vincetoxicum atratum (Bunge) Morren et Decne. Steroids	Others
Cynanoside J is a C₂₁ steroidal glycosides that can be obtained from Cynanchum taihangense. The IC₅₀ values of Cynanoside J for HL-60, THP1, and Caco2 are 6.38, 5.82, and 6.76 μM, respectively. Cynanoside J can be used in cancer research .

HY-N6061

Ophiopogonin C	Ophiopogon japonicus (L. f.) Ker-Gawl. Triterpenes Liliaceae Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Others
Ophiopogonin C, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin C shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC₅₀s of 19.76 μM and 15.51 μM, respectively .

HY-N3504

Ophiopogonin D'	Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Sirtuin
Ophiopogonin D', isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D' shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC₅₀s of 3.09 μM and 3.63 μM, respectively . Ophiopogonin D' activates SIRT1 in a dose-dependent manner .

HY-N12002

Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside	Structural Classification Polysaccharides Source classification Plants Melanthiaceae Saccharides Steroids Paris polyphylla var. yunnanensis (Franch.) Hand.-Mzt.	Others
Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside (compound 9) is a steroidal saponin, which can be obtained from Paris polyphylla var., Yunnan pine (yunnanensis) Isolated .

HY-N0515

Ophiopogonin D	Cardiovascular Disease Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields Steroids	PPAR NF-κB Calcium Channel
Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years .

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